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Dose Response Assessment Introductory Training

December 19, 2016


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Human health risk assessments in the United States are relying more and more on quantitative dose-response assessments to derive a toxicity point of departure. Quantitative dose-response assessments take expertise in USEPA’s Benchmark Dose Software (BMDS). The software is freely available from USEPA , which has been peer reviewed, and is widely accepted by regulatory agencies. BMDS now contains 30 different models. BMDS allows for the maximum likelihood estimate of a dose associated with a response observed in a toxicity test, known as a benchmark response level. The power of this software allows us to account for uncertainty in sample size, high-background response and response variability in the point of departure. The benchmark dose approach is not constrained by doses used in the study and it allows for comparison of responses across studies. BMDS gives a full dose-response curve fitted to the toxicity data and can be used even if a no-observable-adverse-effect level (NOAEL) cannot be identified from a toxicity study.

Dose Response Assessment Introductory Training Material

Waterborne now offers an introductory hands-on class on quantitative dose-response assessments and a customized course on USEPA’s BMDS. This is valuable because USEPA uses this tool to facilitate the application of benchmark dose methods to risk assessments .Waterborne’s experts in human health risk assessment can provide a single introductory course, a series of short courses or a deeper dive into a set of models, for classes up to 30 people. Upon completion of the course, participants should be able to derive and evaluate risk values for both non-cancer and cancer risk assessments.

For more information on our customized introductory class on quantitative dose-response assessments and USEPA’s BMDS, contact Nikki Maples-Reynolds at maples-reynoldsn@waterborne-env.com.