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Case Study

Dietary Risk Assessment

We were tasked by a client to round out a Notice of Filing for an herbicide adding several proposed uses to crops. These new tolerances for residues, as well as newly modeled water concentrations, require a dietary risk assessment. Utilizing EPA’s Dietary Exposure Evaluation Model – Food Commodity Intake Database (DEEM-FCID)/Calendex Software, direct estimates of the intake of the herbicide in individuals were derived.

Initially a review of the latest herbicides registration was conducted to see if drinking water modeling was needed based on the new crop usage. Drinking water exposure was evaluated via several cases and models fitting the crops proposed based on current EPA standard scenarios for groundwater. The toxicity and exposure of the herbicide was evaluated using EPA’s DEEMs model. Acute and chronic dietary risks were calculated with the proposed tolerances and revised water concentrations. After addition of the proposed tolerances and drinking water contribution to the dietary risk cup, we concluded there s no concern of acute or chronic risk to any sub-population. The Notice of Filing was amended with the newer exposure values and calculations of risk. This allowed the client to submit to EPA the newest proposed tolerances for residues of their herbicide.

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