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Continued Expansion: Toxicology Services and Human Health Risk Assessment

October 27, 2015

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Waterborne has recently expanded their dietary risk assessment capabilities and are now offering non-clinical mammalian toxicology expertise and dose-response assessment services that position us to provide clients human health risk assessments. Our new services support registration, compliance, and defense activities associated with FIFRA, pharmaceuticals, personal care products, cosmetic ingredients, industrial chemicals, and food ingredients and additives. Notable hires such as Duane Huggett, Ph.D. and Nikki Maples-Reynolds have grown Waterborne’s expertise to include the design and management of protocol driven non-clinical GLP toxicology studies (e.g. OCSPP, OECD, FDA RedBook), as well as specialized mechanistic studies (e.g. in vitro hepatotoxicity and skin sensitization). Waterborne’s capabilities now extend to non-cancer and cancer dose-response assessment and modeling (e.g., Benchmark Dose Software), critical endpoint evaluation, weight of evidence, data quality and endpoint assessment, white paper document development, uncertainty factor assessment and recommendation, and data gap analysis. In performing hazard assessments, we use quantitative structure–activity relationship (QSAR) models to estimate physical and chemical properties, environmental fate (including biodegradation), toxicity to aquatic organisms, and human health risk.

The addition of non-clinical mammalian toxicology expertise now enables Waterborne to offer human health risk assessment support
for registration efforts, including dietary, drinking water, occupational, and residential risk assessments. Our key scientists now implement dietary exposure assessment modeling (e.g. DEEM) to efficiently connect drinking water, crop residue and tolerance information, and mammalian toxicology endpoint evaluation. Waterborne scientists also have extensive experience and current involvement with all tiers of drinking water assessment that directly impact dietary risk assessments in important ways.

Beyond understanding risk, our innovative scientists have experience developing novel ways to improve human health risk assessment and to strategize and help our partners define where to focus refinement efforts. We have the capacity for statistical and data analysis, ranging from simple to advanced approaches. Coupled with the scientific expertise, our regulatory insight and experience enables us to assist with new product registration and registration review.

Waterborne is very excited to partner in effective, efficient, and competitive ways to provide human health risk assessment and toxicology services within our various product sectors!